​Pathology - IgA Nephropathy ( Berger Disease)

​Pathology - IgA Nephropathy ( Berger Disease)
IgA deposition in the glomerular mesangium is the primary kidney illness that can occur following infections such as viral upper respiratory tract infection, gastrointestinal infection, or flu-like syndrome. It can also be a part of Henoch-Schonlein purpura.
Most frequently observed in children and young adults, with a higher prevalence in males than in females.

Pathology  
Light microscopy reveals focal proliferative glomerulonephritis with diffuse mesangial expansion.
Electron microscopy reveals IgA mesangial deposits.
Exhibits recurring hematuria (red or cola-colored urine) 1-2 days following an upper respiratory or gastrointestinal infection. 

Clinical Symptoms and Signs 
High blood pressure, tiredness, and slight protein in the urine may be evident.
Laboratory results: Elevated serum IgA level in 50% of cases, normal serum complement levels, presence of red blood cells in urine.

Treatment include ACE inhibitors for proteinuria and steroids or immunosuppressants for specific instances.
20%-30% of people develop end-stage renal failure during a span of 20-30 years.
Berger disease is the predominant kind of acute glomerulonephritis in the United States and is widespread in Asia.