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Pathology - IgA Nephropathy ( Berger Disease)
IgA deposition in the glomerular mesangium is the primary kidney illness that can occur following infections such as viral upper respiratory tract infection, gastrointestinal infection, or flu-like syndrome. It can also be a part of Henoch-Schonlein purpura.
Most frequently observed in children and young adults, with a higher prevalence in males than in females.
Pathology
Light microscopy reveals focal proliferative glomerulonephritis with diffuse mesangial expansion.
Electron microscopy reveals IgA mesangial deposits.
Exhibits recurring hematuria (red or cola-colored urine) 1-2 days following an upper respiratory or gastrointestinal infection.
Clinical Symptoms and Signs
High blood pressure, tiredness, and slight protein in the urine may be evident.
Laboratory results: Elevated serum IgA level in 50% of cases, normal serum complement levels, presence of red blood cells in urine.
Treatment include ACE inhibitors for proteinuria and steroids or immunosuppressants for specific instances.
20%-30% of people develop end-stage renal failure during a span of 20-30 years.
Berger disease is the predominant kind of acute glomerulonephritis in the United States and is widespread in Asia.
IgA deposition in the glomerular mesangium is the primary kidney illness that can occur following infections such as viral upper respiratory tract infection, gastrointestinal infection, or flu-like syndrome. It can also be a part of Henoch-Schonlein purpura.
Most frequently observed in children and young adults, with a higher prevalence in males than in females.
Pathology
Light microscopy reveals focal proliferative glomerulonephritis with diffuse mesangial expansion.
Electron microscopy reveals IgA mesangial deposits.
Exhibits recurring hematuria (red or cola-colored urine) 1-2 days following an upper respiratory or gastrointestinal infection.
Clinical Symptoms and Signs
High blood pressure, tiredness, and slight protein in the urine may be evident.
Laboratory results: Elevated serum IgA level in 50% of cases, normal serum complement levels, presence of red blood cells in urine.
Treatment include ACE inhibitors for proteinuria and steroids or immunosuppressants for specific instances.
20%-30% of people develop end-stage renal failure during a span of 20-30 years.
Berger disease is the predominant kind of acute glomerulonephritis in the United States and is widespread in Asia.
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