​Pathology - Kawasaki Disease

​Pathology - Kawasaki Disease 
The cause is yet unidentified, although a malfunction in the regulation of the immune system is seen as a possible explanation.
Typically impacts infants and young children under the age of 5.

Study of diseases and their effects on the body. 
Gross: Impacts vessels of small and medium size, including coronary arteries.
Microscopic: The vessel wall exhibits transmural inflammation and necrosis, accompanied by an infiltration of inflammatory cells.

Clinical manifestations 
The individual is experiencing symptoms such as fever, inflammation of the conjunctiva, lesions on the mucous membranes of the mouth, and swollen lymph nodes in the neck, typically affecting a single node. The individual is experiencing joint pain, swelling in the hands and feet, and redness on the palms and soles of the feet.
Possible complications encompass myocarditis and the formation of coronary artery aneurysms, which have the potential to burst and result in fatality.

Management 
Aspirin and intravenous gamma-globulin are used to prevent the development of coronary aneurysms.
The disease typically resolves on its own, but patients should undergo an echocardiography or cardiac CT scan to assess for proximal coronary aneurysms.