​Pathology - Sarcoidosis

​Pathology - Sarcoidosis
The cause is unclear. While the possibility of immunological malfunction has been suggested.
The highest occurrence is observed in African American women between the ages of 20 and 41.
The tissues most frequently affected are the lung, lymph nodes, spleen, liver, bone marrow, skin, eyes, and salivary glands.

The specimen exhibits a microscopic finding of a noncaseating granuloma with a fibrotic center. The granuloma is surrounded by epithelioid cells and Langhans giant cells. Additionally, there are asteroid bodies (inclusions inside giant cells) and Schaumann bodies (calcium concretions) present. However, they may also be found in other granulomatous conditions.

The individual presents with a range of symptoms including malaise, fever, enlargement of the liver and spleen, difficulty breathing, inflammation of the lung tissue, skin rash characterized by painful nodules, inflammation of many joints, inflammation of the uvea (middle layer of the eye), damage to the central nervous system and peripheral nerves, and a condition where the heart muscle becomes stiff and less able to pump blood efficiently.
Imaging: The chest X-ray reveals the presence of enlarged lymph nodes on both sides of the chest and abnormal lung tissue infiltration. The laboratory results are also available. Reduced total lung capacity. Reduced diffusion capacity of the lungs for carbon monoxide (DLCO). elevated erythrocyte sedimentation rate (ESR). Elevated ACE enzyme activity, excessive levels of calcium in the blood and urine, elevated levels of gamma globulins, decreased responsiveness to skin test antigens


Corticosteroids are prescribed for people who are experiencing symptoms or have complications affecting their organs.