Pathology - Secondary Hyperparathyroidism
Primarily due to chronic renal insufficiency. Parathyroid gland shows diffuse expansion due to hyperplasia of principal cells. Pathophysiology: Reduced l,25-(OH)2 D3 generation from deteriorating kidney function leads to diminished intestinal calcium absorption resulting in hypocalcemia. This condition is additionally exacerbated by elevated calcium excretion from the impaired kidney, leading to higher parathyroid hormone (PTH) levels. Clinical Symptoms and Signs Osteoclastic bone disease with widespread distribution; metastatic calcification in soft tissues. Laboratory results: Low calcium levels, elevated parathyroid hormone (PTH), elevated serum alkaline phosphatase, elevated serum phosphate. Therapy If the disease is severe, the aberrant glands will be surgically removed. Phosphate binders and vitamin D supplementation.
0 Comments
Leave a Reply. |
Kembara XtraFacts about medicine and its subtopic such as anatomy, physiology, biochemistry, pharmacology, medicine, pediatrics, psychiatry, obstetrics and gynecology and surgery. Categories
All
|