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Pharmacology - Acarbose
Action of acarbose causes a delay in the absorption of carbohydrates from the gut.
Method of Operation
It does this by inhibiting intestinal alpha-glucosidase and pancreatic alpha-amylase, which in turn lowers the rise in blood glucose that occurs after a meal. Alpha-glucosidase is the enzyme that is accountable for the breakdown of starches and oligosaccharides, which ultimately results in the production of monosaccharides that are absorbable.
metabolized in the gastrointestinal tract by bacteria and digestive enzymes. The half-life is two hours.
Use in Clinical Settings
Diabetes mellitus type 2 that cannot be treated by any other medications.
Adverse Effects
Discomfort in the gastrointestinal tract, including flatulence and diarrhea.
Action of acarbose causes a delay in the absorption of carbohydrates from the gut.
Method of Operation
It does this by inhibiting intestinal alpha-glucosidase and pancreatic alpha-amylase, which in turn lowers the rise in blood glucose that occurs after a meal. Alpha-glucosidase is the enzyme that is accountable for the breakdown of starches and oligosaccharides, which ultimately results in the production of monosaccharides that are absorbable.
metabolized in the gastrointestinal tract by bacteria and digestive enzymes. The half-life is two hours.
Use in Clinical Settings
Diabetes mellitus type 2 that cannot be treated by any other medications.
Adverse Effects
Discomfort in the gastrointestinal tract, including flatulence and diarrhea.
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