Pharmacology - Amfetamine
Amfetamine is a pharmacological substance. The release of NA from the varicosity results in actions that are comparable to those of epinephrine and NA, although with a lower intensity:activation of the alpha 1 receptor causes vasoconstriction, which in turn raises blood pressure.The stimulation of beta 2 receptors results in bronchodilation. Increased heart rate is the result of beta 1 activation. Is also a powerful stimulant of the central nervous system. Taken up via uptake into the varicosity, then into the vesicle by exchange with NA; the NA, which is now loose in the cytoplasm, is then released by exchange with amfetamine. This is the mode of action. Orally absorbed; plasma half-life is approximately 12 hours. unaltered in the urine that is excreted. Use in Clinical Settings In children, narcolepsy and hyperactivity are seen. Adverse Effects Excessive doses can cause symptoms such as elevated blood pressure, tachycardia, sleeplessness, and psychosis. The development of tolerance, dependency, and addiction is possible.
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