​Pharmacology - Amiloride

​Pharmacology -  Amiloride 
Restricts the reabsorption of salt in the distal nephron; its diuretic effect is only moderately effective.
K+ excretion is decreased as a result.

Method of Operation 
This reduces the amount of sodium that enters the collecting tubule by inhibiting the sodium channel that is located in the luminal membrane.

Orally administered. The beginning of effect of triamterene is more quick than that of amiloride, and its duration of action is shorter.

Clinical Use Given in conjunction with K+-losing diuretics (such as thiazides and loop diuretics) in order to restrict the loss of K+.

Adverse Effects 
A hyperkalemic state that may lead to acidosis.