​Pharmacology - Amitriptyline

​Pharmacology - Amitriptyline 
Decrease in the severity of neuropathic pain caused by amitriptyline.

Method of Operation
 Antidepressants exert their analgesic effects primarily through the inhibition of the opening of neuronal voltage-gated Na+ channels (Nav 1.7 subtype), as opposed to the inhibition of monoamine reuptake. When Na+ channels are blocked, the transmission of pain from the site of nerve damage is reduced.

Ingestion of the medication. Amitriptyline is metabolized by the hepatic P450 enzyme, and nortriptyline is one of its metabolites.
12–24 hours is the half life.

Use in Clinical Settings
Cancer pain, diabetic peripheral neuropathy, and postherpetic neuralgia are all examples of neuropathic pain.

Allergies and Reactions 
antihistamine activity, with nortriptyline producing a lower level of sedation. The antimuscarinic activity causes symptoms such as blurred vision, dry mouth, constipation, and urine retention. Antagonism of the alpha-1-adrenoceptor is at the root of postural hypotension.
Due to cardiac dysrhythmia, severe hypotension, seizure, and central nervous system depression, an overdose has the potential to be deadly. There is a higher likelihood of suicide among younger patients.