​Pharmacology - Amphotericin

​Pharmacology - Amphotericin 
Activities of Amphotericin 
It accomplishes this by attaching to the ergosterol that is present in the membrane of fungal cells (which is absent in mammalian cells) and by increasing the permeability of the membrane.
Absent from the GIT's absorption. a lipid formulation that is administered intravenously; it is capable of crossing the blood–brain barrier in cases of meningitis; it is used topically in the form of a lozenge for oral fungal infections.

Use in Clinical Settings 
Candida, cryptococcal meningitis, histoplasmosis, apergillosis, blastomycosis, coccidiomycosis, and mucormycosis are all examples of fungal infections.

Intravenous administration can cause the following adverse effects: renal toxicity, cardiovascular system toxicity, gastrointestinal tract disturbances, neurological disturbances, anaphylactoid reactions, infusion reactions (fever, headache, chills), myalgia, and arthralgia.