Pharmacology - Aspirin

Pharmacology - Aspirin 
​​Activity of Aspirin 
Reduces inflammation, acts as an analgesic for pain caused by inflammation, and is antipyretic (that is, it lowers temperature), among other benefits. Platelets are prevented from aggregating.

Method of Operation 
Acetylation of cyclooxygenases that is irreversible and has a COX-1 selectiveity that is weak.

Orally administered. A quick hydrolysis to salicylate occurs, but the effects remain longer than expected because the COX has been rendered inactive and a new enzyme must be created. The half-life is only thirty minutes.

Use in Clinical Settings 
In myocardial infarction, the primary application is as an antithrombotic. When it comes to musculoskeletal problems, other nonsteroidal anti-inflammatory drugs (NSAIDs) are chosen for their anti-inflammatory and analgesic effects.

Effects That Are Bad 
The presence of gastrointestinal problems, including bleeding from the stomach. Salicylism, which includes tinnitus, vertigo, and a reduction in hearing, can be caused by excessive dosages. Additionally, allergic responses and renal toxicity can occur on occasion.
In children who have been infected with a virus, it has the potential to bring about Reye's syndrome, which is characterized by encephalopathy and liver dysfunction.

It is not appropriate for usage in children. It has the potential to escalate the effects of warfarin, which can lead to bleeding.
It is not recommended for use in the treatment of gout because it inhibits the effect of uricosuric drugs and decreases the amount of urate that is excreted.