Pharmacology - Azathioprine

Pharmacology - Azathioprine 
Enhances the immunological response by inhibiting the clonal expansion of T and B cells during the induction phase of the immune response.

Method of Operation 
This compound has a cytotoxic effect on cells that are dividing and interferes with the synthesis of purines.

Administered either orally or through intravenous infusion. Metabolism results in the formation of mercaptopurine (mcp), which is the cytotoxic moiety that exerts its effects by disrupting the metabolism of purine nucleotides. Because of xanthine oxidase, Mcp is rendered inactive.

Use in Clinical Settings 
It is utilized for the purpose of preventing graft-versus-host disease as well as the prevention of organ and tissue transplant rejection. Also utilized in the treatment of autoimmune illnesses and chronic inflammatory conditions, such as rheumatoid arthritis.

Adverse Effects 
Myelotoxicity, which is dose-responsive. disturbed gastrointestinal tract, hypersensitivity reactions (such as skin rashes, arthralgia, and so on).

In order to detect myelosuppression, blood should be monitored.