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Pharmacology - Benzocaine
How Benzocaine Works
Blocks the conduction of action potentials in nerves. At lower concentrations, it blocks pain fibers with smaller diameters.
Effect Mechanism
Benzocaine is primarily bound to protein in the body and has a significantly weaker base than the majority of LAs (pKa = 2.5). It can enter the Na+ channel through the membrane lipid and is not usage dependent.
For external use as a powder, ointment, or gel (poor solubility in water).
Because it dissolves lipids quickly, it can cross mucosal membranes with ease.
Application in Clinical Practice
This substance is exclusively for use in surface anesthesia procedures, such as nasogastric tube installation and wound and burn pain management. And in throat lozenges as well.
Negative Impacts
Possible adverse effects; nonetheless, it is often safe and found in many over-the-counter formulations.
How Benzocaine Works
Blocks the conduction of action potentials in nerves. At lower concentrations, it blocks pain fibers with smaller diameters.
Effect Mechanism
Benzocaine is primarily bound to protein in the body and has a significantly weaker base than the majority of LAs (pKa = 2.5). It can enter the Na+ channel through the membrane lipid and is not usage dependent.
For external use as a powder, ointment, or gel (poor solubility in water).
Because it dissolves lipids quickly, it can cross mucosal membranes with ease.
Application in Clinical Practice
This substance is exclusively for use in surface anesthesia procedures, such as nasogastric tube installation and wound and burn pain management. And in throat lozenges as well.
Negative Impacts
Possible adverse effects; nonetheless, it is often safe and found in many over-the-counter formulations.
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