​Pharmacology - Chloroquine

​Pharmacology - Chloroquine 
Interaction of Chloroquine 
A medication that is schizonticidal that destroys malarial parasites that are found in red blood cells.

Method of Operation
 It does this by inhibiting haem polymerase, which is ordinarily responsible for degrading haem, which in turn renders it harmless to the parasite. Molecules of haem, which are poisonous, accumulate and ultimately kill the parasite.

It concentrates in parasitized erythrocytes when it is administered orally (or subcutaneously or intravenously in cases of severe falciparum malaria). Eliminated gradually; the half-life is fifty hours, although a residue remains for a longer period of time.

Use in Clinical Settings
Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae are susceptible to acute bouts of benign malaria.
 intended for the purpose of chemoprophylaxis against benign malaria as well as chloroquine-sensitive falciparum malaria.
For the purpose of treating lupus erythematosus and rheumatoid arthritis

Allergies and Reactions 
Not many when it is used for chemoprophylaxis. When used to treat an acute attack, bigger doses have the potential to produce gastrointestinal (GI) problems, disorientation, and urticaria. Having bolus intravenous infusions can result in dysrhythmias.

Chloroquine resistance is becoming more widespread.