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Pharmacology - Colestyramine
Analysis of Colestyramine's Pharmacological Effects
This particular resin is a bile acid binding agent, and its primary function is to reduce LDL cholesterol levels.
Mode of Action
It is a medication with a positive charge that binds to the bile acids, which have a negative charge, and prevents them from being completely absorbed. By doing so, the pool of bile acids in the liver is reduced, which in turn reduces the amount of C that is stored in the liver.
Because of this, the production of LDL receptors is stimulated, which ultimately leads to an increase in the amount of LDL that is taken up by liver cells. Additionally, the medicine reduces C by reducing the amount of it that is absorbed from the gastrointestinal tract.
Since it is taken orally and is not absorbed, there are no negative effects on the body's systemic functioning.
Use in Clinical Settings
Hypercholesterolaemia, often used with a statin.
Adverse Effects
Disturbances of the gastrointestinal tract, including constipation, bloating, and occasionally diarrhea.
The absorption of fat-soluble vitamins, statins, gemfibrozil, and other medications (such as digoxin, thiazides, thyroxine, steroids, iron salts, and folic acid) is inhibited.
Analysis of Colestyramine's Pharmacological Effects
This particular resin is a bile acid binding agent, and its primary function is to reduce LDL cholesterol levels.
Mode of Action
It is a medication with a positive charge that binds to the bile acids, which have a negative charge, and prevents them from being completely absorbed. By doing so, the pool of bile acids in the liver is reduced, which in turn reduces the amount of C that is stored in the liver.
Because of this, the production of LDL receptors is stimulated, which ultimately leads to an increase in the amount of LDL that is taken up by liver cells. Additionally, the medicine reduces C by reducing the amount of it that is absorbed from the gastrointestinal tract.
Since it is taken orally and is not absorbed, there are no negative effects on the body's systemic functioning.
Use in Clinical Settings
Hypercholesterolaemia, often used with a statin.
Adverse Effects
Disturbances of the gastrointestinal tract, including constipation, bloating, and occasionally diarrhea.
The absorption of fat-soluble vitamins, statins, gemfibrozil, and other medications (such as digoxin, thiazides, thyroxine, steroids, iron salts, and folic acid) is inhibited.
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