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Pharmacology - Cyclophosphamide
By establishing covalent bonds with guanine residues on each strand of DNA, cyclophosphamide crosses-links DNA, which disrupts cell division and triggers death. Administration via mouth or intravenous injection leads to its phosphoramide mustard and acrolein metabolism in the liver.
Application in Clinical Practice
Various malignancies, include ovarian and breast tumors, osteogenic sarcoma, soft tissue sarcoma, and chronic lymphocytic leukemia.
Negative Impacts
Irritability, vomiting, myelosuppression, acrolein-mediated hemorrhagic cystitis, and hair loss.
Affecting gametogenesis is possible. Acute non-lymphocytic leukemia can develop with prolonged use.
By establishing covalent bonds with guanine residues on each strand of DNA, cyclophosphamide crosses-links DNA, which disrupts cell division and triggers death. Administration via mouth or intravenous injection leads to its phosphoramide mustard and acrolein metabolism in the liver.
Application in Clinical Practice
Various malignancies, include ovarian and breast tumors, osteogenic sarcoma, soft tissue sarcoma, and chronic lymphocytic leukemia.
Negative Impacts
Irritability, vomiting, myelosuppression, acrolein-mediated hemorrhagic cystitis, and hair loss.
Affecting gametogenesis is possible. Acute non-lymphocytic leukemia can develop with prolonged use.
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