​Pharmacology - Disopyramide

​Pharmacology - Disopyramide 
Anti-dysrhythmic medication 

Method of Operation 
In accordance with the Vaughan Williams classification, it is classified as class 1a. The action of blocking open and inactivating Na+ channels in the cell membrane is a "use-dependent" activity that reduces the rate of phase 0 depolarization, resulting in an increase in the effective refractory period and a slowing of AV conduction. Additionally, it causes a slowdown of the repolarization of the action potential, which is a class III activation.

In addition to intravenous administration. The half life is between five and ten hours. Half of it is metabolized in the liver, while the other half is eliminated untouched by the kidney.

Use in Clinical Settings 
Dysrhythmia of the supraventricular and, more frequently, the ventricular cavities

Effects That Are Bad
Effects similar to those of atropine include hazy eyesight, dry mouth, constipation, and retention of your urine. An inotropic activity that is negative. The antimuscarinic activity of procainamide is considered to be lower than that of either disopyramide or quinidine. There is a possibility that these medications' class III activities will result in torsade de pointes.