Pharmacology - dobutamine
A cardiac stimulant, it raises the contractility of the heart and, as a result, the output of the heart. Vasoconstriction is minimal, and it has a lessening effect on the rate at which the heart beats. Mode of Action It primarily acts on beta 1-receptors, which results in an increase in cAMP that is mediated by G-proteins. This, in turn, causes an increase in calcium influx in the cardiac myocytes. The beta 2-receptors are only marginally affected. Absorption / Distribution / Elimination Inactivated by MAO and COMT, the drug is administered intravenously at a plasma half life of two minutes. Use in Clinical Settings Shock caused by the heart. Decompensated congestive heart failure. Dirhythmias are one of the adverse effects.
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