​Pharmacology - Doxycycline

​Pharmacology - Doxycycline 
Bacterial protein synthesis is hindered by doxycycline because it reversibly inhibits the binding of tRNA to the mRNA codons in the 30s subunit and competes with it for the A site of the ribosome.

Orally administered; milk and iron, magnesium, and calcium supplements reduce absorption.

Use in Clinical Settings
It is the preferred medication for treating brucella, chlamydial, and rickettsial infections. Mycoplasma and Haemophilus influenzae infections are effectively treated. Used for the treatment and prevention of malaria as well as sinusitis, prostatitis, syphilis, and Lyme disease. 

Potential Side Effects
Tickle, tinnitus, flushing, anorexia, gastrointestinal problems, tooth discoloration. Infrequent: hypersensitivity reactions, hepatotoxicity, pancreatitis.