​Pharmacology - Entacapone

​Pharmacology - Entacapone
It works in conjunction with the anti-parkinsonian effects of levodopa and carbidopa medications. This compound enhances the effects of catecholamines.

Method of Operation 
The reversible inhibition of COMT in the periphery lowers the breakdown of levodopa (similar to peripheral dopa decarboxylase inhibitors), which enables a greater quantity of levodopa to enter the brain.

Oral admin. Due to its short half life of one hour, daily dosing must be performed multiple times.

Use in Clinical Settings 
When used in conjunction with levodopa or carbidopa therapy, particularly for patients exhibiting symptoms of "end of dose" impairment.
In and of itself, there is no anti-Parkinsonian effect.

Adverse Effects 
When levodopa and carbidopa are taken together, the undesirable effects of both medications are exacerbated. Symptoms include dyskinesia, nausea, and diarrhea. Postural hypotension is caused by. There are hallucinations. Anxiety and a tendency to sleep.