​Pharmacology - Flecainide

​Pharmacology - Flecainide
Flecainide's antidysrhythmic action is described as below 

Method of Operation 
According to the Vaughan Williams classification, it is classified as class 1c. Na+ channels that are open are blocked preferentially.
Reduces the rate of phase 0 depolarization, which results in an increase in the effective refractory period and a slowing of AV conduction during the procedure. The rate at which it associates with sodium channels and dissociates from them is slower than that of either substances Ia or Ib.

Oral admin.20 hours is the half life. Most of the time, it is unaltered in the urine. Propafenone is metabolized by the liver at a faster rate and has a shorter half life, which ranges from five to ten hours.

Use in Clinical Settings 
To prevent atrial fibrillation with paroxysmal episodes. Extremely severe ventricular dysrhythmia, with no response to any other medicines.

Adverse Effects 
Raise the probability of experiencing dysrhythmia. Possibly increases the risk of death as a result of ventricular fibrillation following an infarction. Use with caution is required. Those patients who have structural heart problems should avoid this. An inotropic activity that is negative.