​Pharmacology - Flucloxacillin

​Pharmacology - Flucloxacillin
Bactericidal action of flucloxacillin occurs through interfering with bacterial cell wall formation during cell division.

Mode of Action 
 Connects with the enzyme responsible for attaching the peptide chain of the freshly synthesized "block" to the backbone of the peptidoglycan cell wall and blocks its activity.
Administration options include sublingual, intramuscular, or gradual intravenous infusion. (Probenecid blocks its passage into all bodily fluids; it is therefore eliminated in urine).

Use in Clinical Settings
 Infections caused by staphylococci that resist penicillin.

Resistance 
Reduced sensitivity is observed in certain pneumococci, meningococci, and gonococci.

Potential Side Effects 
Irritations of the gastrointestinal tract; hypersensitivity reactions (rash, itching, swelling, fever, pain, anaphylaxis). In very rare cases: cholestatic jaundice and hepatitis.