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Pharmacology -Flurouracil
Action of Fluorouracil
Interferes with the production of dTMP and thus with DNA synthesis.
Mode of Action Gives rise to a counterfeit nucleotide and Inhibits thymidylate synthetase. Given i.v.
Considering i.v. Clinical Use
Cancers of GIT (gastric, colorectal ), pancreas, breast; malignant skin diseases.
Negative Outcomes
Myelosuppression, gastrointestinal problems, and mucositis are uncommon. Given long term: desquamation of feet & hands.
Folic acid, a tetrahydrofolate derivative, should be used as a "rescue" after high-dose regimens to reduce harmful effects on the GIT mucosa and bone marrow.
Action of Fluorouracil
Interferes with the production of dTMP and thus with DNA synthesis.
Mode of Action Gives rise to a counterfeit nucleotide and Inhibits thymidylate synthetase. Given i.v.
Considering i.v. Clinical Use
Cancers of GIT (gastric, colorectal ), pancreas, breast; malignant skin diseases.
Negative Outcomes
Myelosuppression, gastrointestinal problems, and mucositis are uncommon. Given long term: desquamation of feet & hands.
Folic acid, a tetrahydrofolate derivative, should be used as a "rescue" after high-dose regimens to reduce harmful effects on the GIT mucosa and bone marrow.
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