Pharmacology - Flurouracil

Pharmacology -Flurouracil 
​Action of Fluorouracil 
Interferes with the production of dTMP and thus with DNA synthesis.
Mode of Action Gives rise to a counterfeit nucleotide and Inhibits thymidylate synthetase. Given i.v. 
Considering i.v. Clinical Use 
Cancers of GIT (gastric, colorectal ), pancreas, breast; malignant skin diseases.
Negative Outcomes 
Myelosuppression, gastrointestinal problems, and mucositis are uncommon. Given long term: desquamation of feet & hands.
Folic acid, a tetrahydrofolate derivative, should be used as a "rescue" after high-dose regimens to reduce harmful effects on the GIT mucosa and bone marrow.