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Pharmacology - Furosemide
The action of furosemide
By blocking the reabsorption of sodium chloride in the thick ascending loop, it causes an abundance of urine to be produced.
The excretion of Ca2+ and Mg2+ is increased, whereas the excretion of uric acid is also decreased.
Method of Operation
Through its interaction with the chloride binding site, it is able to inhibit the Na+/K+/2Cl- co-transporter that is located in the luminal membrane.Orally administered (in the event of an emergency, intravenous administration may be made), well absorbed, and reaches the site of action via being secreted into the proximal tubule. The half-life is ninety minutes.
Use in Clinical Settings
In addition to hypercalcemia and hyperkalemia, pulmonary oedema, chronic heart failure, and ascites caused by liver cirrhosis are also present.
Side Effects
Some of the potential adverse effects include hypokalemic alkalosis, hyperuricemia (which can lead to gout), hypovolemia and hypotension in elderly patients, and reversible ototoxicity.
The action of furosemide
By blocking the reabsorption of sodium chloride in the thick ascending loop, it causes an abundance of urine to be produced.
The excretion of Ca2+ and Mg2+ is increased, whereas the excretion of uric acid is also decreased.
Method of Operation
Through its interaction with the chloride binding site, it is able to inhibit the Na+/K+/2Cl- co-transporter that is located in the luminal membrane.Orally administered (in the event of an emergency, intravenous administration may be made), well absorbed, and reaches the site of action via being secreted into the proximal tubule. The half-life is ninety minutes.
Use in Clinical Settings
In addition to hypercalcemia and hyperkalemia, pulmonary oedema, chronic heart failure, and ascites caused by liver cirrhosis are also present.
Side Effects
Some of the potential adverse effects include hypokalemic alkalosis, hyperuricemia (which can lead to gout), hypovolemia and hypotension in elderly patients, and reversible ototoxicity.
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