​Pharmacology - Glyceryl Trinitrate

​Pharmacology - Glyceryl Trinitrate
As a result of its ability to relax and relax vascular smooth muscle, particularly venular smooth muscle, glyceryl trinitrate has the ability to (i) reduce cardiac effort and, consequently, metabolic demand, and (ii) increase the perfusion and oxygenation of heart muscle. in the field of pharmacology.

The mechanism of action involves the production of nitric oxide (NO) within the cell, which in turn stimulates protein kinase G (PKG) and decreases the contraction of the muscle.

The effects of glyceryl trinitrate, which can be administered as a sublingual pill or spray, are immediate and last for approximately thirty minutes. The effects of the transdermal patch can persist for twenty-four hours. Can be administered intravenously. Oral administration of isosorbide mononitrate with a half-life of four hours and a slow-release formulation is available.

Use in Clinical Settings 
Sublingual administration is used to prevent and treat stable angina, while intravenous administration of glyceryl trinitrate is used to treat unstable angina. Nitrorates are also utilized in the treatment of chronic heart failure;

Adverse Effects
Headache as a result of vasodilatation; postural hypotension as a result of vasomotor tone; extended use leads to tolerance; methaemoglobinemia (rare) with continued high doses of the medication.
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