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MEDICINE 

​Pharmacology -  Hydrochlorothiazide

12/16/2023

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​Pharmacology -  Hydrochlorothiazide 
As a result of limiting the reabsorption of sodium chloride in the distal tubule, it causes a moderate degree of diuresis.
Increases the excretion of both K+ and H+. The excretion of Ca2+ and uric acid is decreased, whereas the excretion of magnesium is increased. A vasodilator effect is seen.

The mode of action involves inhibiting the co-transporter of sodium ions and chloride ions in the luminal membrane of the distal convoluted tubule.

When taken orally, the drug is released into the proximal tubule, which allows it to reach the site of action. The half-life is ninety minutes.

Use in Clinical Settings 
Blood pressure that is high. Additionally, kidney stones, nephrogenic diabetic insipidus, and moderate heart failure are also present.

Side Effects 
Potassium deficiency, metabolic alkalosis, hyperuricemia (which can lead to gout), increased insulin demand, and erectile dysfunction are all symptoms of this condition.
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