​Pharmacology - Hydrocortisone

​Pharmacology - Hydrocortisone 
Utilization of Hydrocortisone 
A reduction in autoimmune and hypersensitivity reactions, as well as in chronic inflammation.
A permissive influence on lipolytic hormones, decreased glucose uptake and utilization, increased catabolism, and decreased protein synthesis are all metabolic effects. Gluconeogenesis is also included in this category.
Action of negative feedback on the pituitary gland and the hypothalamus of the ant.

In order to exert their effects, GCs engage in interactions with intracellular receptors that regulate the transcription of particular genes. 

Drugs that are comparable
Short-acting prednisolone, which can be taken orally or injected. The intermediate-acting triamcinolone has a topical and intramuscular application. Longer-acting dexamethasone, which can be taken orally or injected. Through inhalation, beclometasone is administered.
Short-lived and effective. Administered topically, orally, or by injection. As a result of the necessity of protein synthesis for mediators and enzymes, the primary effects happen only after two to eight hours have passed.

Use in Clinical Settings 
Inflammatory, hypersensitive, and autoimmune illnesses (such as rheumatoid arthritis, asthma, and anaphylactic shock, among others); to prevent transplant rejection; on some tumors.
In cases of adrenal failure, replacement therapy is administered.