Pharmacology - Ibuprofen

Pharmacology - Ibuprofen 
​​The drug ibuprofen
Reduces inflammation, acts as an analgesic for pain caused by inflammation, and is antipyretic, which means it lowers or lowers the temperature.

Mode of Action 
The inhibition of COX-1 is reversible, but the inhibition of COX-2 is modest.

Oral administration results in a half-life of two hours.

Use in Clinical Settings
Conditions characterized by inflammation, such as rheumatoid arthritis, osteoarthritis, and musculoskeletal illnesses; dysmenorrhea-related symptoms.

Adverse Effects 
Disturbances of the gastrointestinal tract, including bleeding from the stomach; headaches and dizziness, which occur less frequently; allergic responses on occasion; and renal toxicity, which occurs seldom. There is an increased risk of harmful effects when coupled with other nonsteroidal anti-inflammatory drugs (NSAIDs). The patent ductus arteriosus is closed with this device.

Drugs that are comparable 
diclofenac: (half-life of one to two hours; moderate potency). Ketoprofen, with a half-life of around two hours; Naproxen, which is more potent and has a half-life of ten to fourteen hours; ketorolac, with a half-life of four to ten hours and a selective COX-1 activity; and piroxicam, with a half-life of 57 hours, a common GIT toxicity and a non-selective COX activity.