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Pharmacology - Imipenem
Imipenem is a bactericidal agent that prevents bacteria from dividing by interfering with their cell wall formation.
Mode of Action
'Building blocks' are peptide chains that attach to the backbone of peptidoglycan cell walls; this enzyme is bound to and inhibited by this molecule. Given by i.v. infusion. Enters the cerebrospinal fluid (CSF) and all other bodily fluids similarly. Must be administered with cilastatin, an inhibitor of the relevant enzymes, because it is inactivated by renal enzymes.
Use in Clinical Settings
Anaerobic, Gram-positive, and Gram-negative bacteria are all targets of this broad-spectrum antibiotic. Uneffective against methicillin-resistant Staphylococcus aureus. Medicated for the treatment of serious polymicrobial infections that might occur in healthcare facilities, such as septicaemia, pneumonia, and complex urinary tract infections.
Potential Side Effects
allergic reactions, rashes, and gastrointestinal issues.
Imipenem is a bactericidal agent that prevents bacteria from dividing by interfering with their cell wall formation.
Mode of Action
'Building blocks' are peptide chains that attach to the backbone of peptidoglycan cell walls; this enzyme is bound to and inhibited by this molecule. Given by i.v. infusion. Enters the cerebrospinal fluid (CSF) and all other bodily fluids similarly. Must be administered with cilastatin, an inhibitor of the relevant enzymes, because it is inactivated by renal enzymes.
Use in Clinical Settings
Anaerobic, Gram-positive, and Gram-negative bacteria are all targets of this broad-spectrum antibiotic. Uneffective against methicillin-resistant Staphylococcus aureus. Medicated for the treatment of serious polymicrobial infections that might occur in healthcare facilities, such as septicaemia, pneumonia, and complex urinary tract infections.
Potential Side Effects
allergic reactions, rashes, and gastrointestinal issues.
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