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Pharmacology - Tiagabine An anticonvulsant medication Method of Operation As a result of blocking the reuptake of GABA into GABAergic nerve terminals and glia via GAT-1, synaptic GABA concentration is increased, and neuronal activity is reduced. To be taken orally. P450 metabolism occuring in the liver. Seven hours is the half life. Use in Clinical Settings In the treatment of partial seizures, used in conjunction with other medicines. Adverse Effects Symptoms include weariness, dizziness, drowsiness, and disorientation. Nausea is it. 
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