​Pharmacology -Lidocaine

​Pharmacology -Lidocaine 
The antidysrhythmic and local anesthetic properties of lidocaine belong to the field of pharmacology.

Mode of Action 
According to the Vaughan Williams classification, it is classified as class 1b. It does this by blocking open and inactivated Na+ channels in the cell membrane (it demonstrates 'use-dependence,' which means it is more likely to work in tissue that has been injured and depolarized). If you block the Na+ channel, the rate of phase 0 depolarization will decrease, which will result in an increase in the effective refractory period and a slowdown in AV conduction.

Due to  a very high first-pass metabolism, oral administration is not an option .
A short half life that is around two hours. Consequently, cytochrome P450 metabolism is involved. Both mexiletine and tocainide are effective when taken orally.

Use in Clinical Settings 
The treatment and prevention of ventricular fibrillation, particularly when myocardial infarction has occurred when it occurs. Additionally, digoxin leads to dysrhythmias.

Adverse Effects 
Unwanted effects on the central nervous system include sleepiness, tremors, and convulsions.