​Pharmacology - Lithium

​Pharmacology - Lithium 
"stabilizer" of mood 

Method of OperationLacking a strong foundation. Considering that Li+ is a group 1 element, similar to Na+ and K+, there is a hypothesis that suggests it disrupts the transport of ions across membranes, possibly affecting the reuptake of neurotransmitters. Other potential mechanisms include actions on the metabolism of phosphatidylinositol and on glycogen synthase kinase. Oral admin. Over the course of two weeks, the accumulation of lithium in the body is caused by the act of taking lithium into cells.

It is of utmost importance to monitor the serum Li+ concentration in order to guarantee an effective therapeutic concentration while minimizing the potential for toxicity. This is because the therapeutic index is low. These include antipsychotic medications (olanzapine) and certain antiepileptic medications (lamotrigine, valproate), among others.

Use in Clinical Settings
 In unipolar depression, bipolar disorder, sometimes known as manic-depressive disorder, and mania, as well as as an adjuvant to other medicines.
The clinical effect manifests itself over a period of three to four weeks.

Allergies and Reactions 
Symptoms include diarrhea, tremors, and confusion. Toxic effects on the kidneys, some of which include nephrogenic diabetes insipidus and dehydration.
Inhibits the thyroid's normal function. Epileptic seizures, unconsciousness, and death are the outcomes of an overdose. A great number of medication interactions, such as those with diuretics.