​Pharmacology - Loperamide

​Pharmacology - Loperamide 
Operation of Loperamide 
decreases the motility and secretions of the intestines. The slower transit time enables a greater amount of fluid absorption as well as a greater amount of solid stools.

Method of Operation 
The inhibition of peristalsis occurs when an agonist acts on μ opioid receptors in the myenteric plexus of the gut. There are few central effects, including analgesia and addiction, because the effects can be in the central nervous system.
by the use of naloxone. In contrast to codeine, loperamide and diphenoxylate are able to achieve modest concentrations in the central nervous system, and as a result, they have little central effects, including analgesia and addiction.

Ingestion of the medication. It is metabolized by the cytochrome P450 system in the liver.The half-life is ten hours. Following hydrolysis, diphenoxylate is converted into an active metabolite.

Use in Clinical Settings
Diarrhea that is acute. Diarrhea that is persistent and is connected with having inflammatory bowel disease. A combination formulation containing atropine and diphenoxylate is the most usual way that it is administered.

Side Effects 
Symptoms include drowsiness and nausea. stomach cramping and constipation are symptoms.
An overdose may result in depression of the central nervous system.