​Pharmacology - Metformin

​Pharmacology - Metformin 
Metformin's action brings about a reduction in the concentration of glucose.

Method of Operation 
AMP-activated protein kinase is activated, which results in the inhibition of gluconeogenesis in the liver. Also has the potential to increase tissue sensitivity to insulin. helps tissues absorb more glucose into their cells.

Orally administered. The half-life is three hours. Predominantly eliminated in urine without any changes (should be avoided in people who have renal insufficiency).

Use in Clinical Settings
Diabetes type 2 (either by itself or in combination with other oral hypoglycemic medications). It is very helpful for those who are fat.

Effects That Are Bad
The symptoms of anorexia and gastrointestinal distress, including diarrhea, which can lead to a loss of weight. Occasionally causes lactic acidosis, which has the potential to be lethal. In contrast to sulphonylureas, does not result in hypoglycemia occurring.