​Pharmacology - Minoxidil

​Pharmacology -  Minoxidil 
Reduces blood pressure and causes vascular dilatation that is noticeable and long-lasting.

The mechanism of action involves activating K+ channels, which in turn hyperpolarizes the membrane, and activates actin, which inhibits voltage-dependent Ca++ channels, hence lowering the contraction of K+ channels.

Orally administered. About four hours is the half-life.

Use in clinical settings 
Hypotension of the most severe kind.Additionally used as a topical treatment for baldness.

Adverse Reaction
As a result of salt and water retention, tachycardia, and angina, the medication is administered in conjunction with a loop diuretic and a beta blocker. Hirsutism .