​Pharmacology - Naloxone

​Pharmacology - Naloxone 
An action of naloxone 
opposes the effects that opioid medications have on the body. It has the potential to create hyperalgesia in situations, such as stress, where endogenous opioids might be working.

Method of Operation 
This substance acts as a competitive antagonist for opioids at the μ, delta, and kappa receptors.
Administered intravenously, intramuscularly, or subcutaneously (with a very poor oral bioavailability). After conjugation with glucuronic acid in the liver, the half life is only one to two hours. The effect of naltrexone is prolonged by an active metabolite that has a half life of thirteen hours, despite the fact that it is orally active and has a half life of four hours.

Use in Clinical Settings
Coma and respiratory depression brought on by an opiate overdose are treated with this medication. In order to assist in the treatment of addiction to alcohol and opioids, the longer-acting form of naltrexone is utilized.

Adverse Effects
Exempt from any significant adverse effects. It is possible for opiate users to have withdrawal symptoms.