​Pharmacology - Pethidine

​Pharmacology - Pethidine 
The action of pethidine 
This is analgesia. To feel euphoric. Dependence, both physically and psychologically? Respiratory depression may occur. This inhibits the motility of the gut. (Tachycardia is seen as a result of the antimuscarinic actions of pethidine.)

Method of Operation 
For the purpose of inhibiting pain transmission, it activates μ opioid receptors in both the brain and the spinal cord. There is a possibility that activation of kappa receptors will have an extra impact on the transmission of pain in the spinal cord. has the potential to prevent the activation of the sensory nerve terminals.

Administration of oral and i.m. prone to hydrolysis and oxidation by P450; the half-life ranges from three to five hours. It is also possible to obtain fentanyl in the form of a patch for transdermal administration or for long-term effects. Remifentanil has a half-life that is exceedingly brief (0.1 hours).

Use in Clinical Settings
Pain that ranges from moderate to severe. Does not lessen the contractions of the uterus, which is a preferred treatment for labor discomfort.
In order to provide analgesia during surgical procedures, intravenous administration of remifentanil and sufentanil is performed.

Adverse Effects
Dizziness, nausea, vomiting, sleepiness, and constipation (at a lower frequency than with morphine). These effects include tolerance, dependency, and withdrawal. A coma with respiratory depression is the result of higher doses.