Pharmacology - Pilocarpine

Pilocarpine 

An agonist of the muscarinic receptor (a medication that is similar to bethanechol) The drug pilocarpine

Actions
The activities of parasympathomimetic include the contraction of smooth muscle (such as the gut, the bladder, and the pupil), the reduction of the rate and force of the heartbeat, glandular secretion (such as salivary, perspiration, and stomach acid), and the inhibition of the release of neurotransmitters.

Method of Action 
The effect in glaucoma is caused by the interaction with M3 receptors, which couple to Gq in order to raise the amounts of IP3 and DAG contained within the cells. The constriction of the pupil helps to facilitate the outflow of aqueous humor and reduces the pressure inside the eye.

The process of absorbing, distributing, and eliminating 
The effects of pilocarpine, which is administered in the form of eye drops, are effective for a whole day. It takes many days for a slow delivery system that is put beneath the eyelid to take effect.

Use in Clinical Settings 
The narrow and broad angle forms of glaucoma. Use bethanechol to enhance the motility of the intestines or to stimulate the emptying of the bladder.

Adverse Effects 
eyesight that is blurry as a result of ciliary muscle contraction. Other than that, there are relatively few unintended effects because the systemic absorption of the medicine that is given topically is quite limited. Bronchoconstriction is a potential side effect of bethanechol.