Pharmacology - Piperacillin

Pharmacology - Piperacillin 
Piperacillin inhibits bacterial cell wall production and is thus bactericidal.
Mode of Action 

Connects to the enzyme responsible for attaching the peptide chain of the freshly synthesized "building blocks" to the backbone of the peptidoglycan cell wall and prevents its activity. To prevent inactivation by beta-lactamases in bacteria, this medication is typically administered alongside tazobactam.

Administered intravenously or drip-fed. Eliminated in urine after passing through all bodily fluids (probenecid blocks this).

Medical Use
 infected with Pseudomonas aeruginosa and other Gram-negative bacteria.

Resistance
 Not effective against staphylococci because of beta-lactamase (unless used in conjunction with tazobactam, a beta -lactamase inhibitor) and streptococci because of mutated transpeptidase, an enzyme that hinders beta-lactam binding.

Precautions to Take 
Anaphylaxis, gastrointestinal problems, pseudomembranous colitis, rashes, urticaria, angioedema, fever, arthralgia, and hypersensitivity responses.