​Pharmacology - Promethazine

​Pharmacology - Promethazine
The antiemetic. Stimulant or. The activities of histamine in the periphery are also prevented by this substance. To treat hay fever, use.

Method of Operation 
At H1 receptors, a competitive antagonist and reversible antagonist. Blocking H1 receptors in the vestibular nuclei and in the "vomiting center" is the mechanism that underlies the antiemetic activity of alcohol.

Half life is ten hours. The first-pass metabolism is significant. The half-life of meclizine is longer.

Use in Clinical Settings
In addition to motion sickness, other emesis of vestibular origin, such as Meniere's disease, are also included. During the early stages of pregnancy, vomiting it up. Esophagus brought on by local impulses in the stomach that are mediated by the vagus nerve.

Adverse Reactions 
The use of sedatives might not be desirable because they are risky for activities such as driving. The elderly are prone to confusion. On the other hand, cinnarizine and cyclizine are less sedative. mouth dryness (an effect of anticholinergics).
depression in infants under 2y.
respiratory conditions that could be fatal