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Pharmacology - Quinupristin + Dalfopristin
Quinupristin and Dalfopristin work together to prevent bacteria from making proteins by preventing the conversion of messenger RNA into proteins.
Action Process
Dalfopristin prevents aa-tRNA from attaching to the ribosome and preventing peptide bond synthesis; quinupristin causes peptidyl-tRNA to dissociate. Half life is one to three hours; administered intravenously; processed by the liver. The action of ciclosporin, midazolam, nifedipine, and antidysrhythmics (lidocaine, disopyramide) is enhanced because it inhibits metabolism.
Practical Applications in Healthcare
The most severe Gram-positive infections that do not respond to other antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), skin and soft tissue infections, pneumonia contracted in a hospital setting, and vancomycin-resistant Enterococcus faecium.
Potential Side Effects
gastrointestinal side effects, headache, muscular and joint discomfort, rash, pruritis, reactions at the injection site, low white blood cell count, anemia.
Quinupristin and Dalfopristin work together to prevent bacteria from making proteins by preventing the conversion of messenger RNA into proteins.
Action Process
Dalfopristin prevents aa-tRNA from attaching to the ribosome and preventing peptide bond synthesis; quinupristin causes peptidyl-tRNA to dissociate. Half life is one to three hours; administered intravenously; processed by the liver. The action of ciclosporin, midazolam, nifedipine, and antidysrhythmics (lidocaine, disopyramide) is enhanced because it inhibits metabolism.
Practical Applications in Healthcare
The most severe Gram-positive infections that do not respond to other antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), skin and soft tissue infections, pneumonia contracted in a hospital setting, and vancomycin-resistant Enterococcus faecium.
Potential Side Effects
gastrointestinal side effects, headache, muscular and joint discomfort, rash, pruritis, reactions at the injection site, low white blood cell count, anemia.
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