Pharmacology - Succinylcholine

Succinylcholine 
An action that causes skeletal muscle to become temporarily paralyzed.

Mode of Action 
 A sustained depolarization of the muscular membrane is produced as a result of action on nicotinic receptors. This causes the Na+ channels, which are responsible for spreading the action potential throughout the muscle, to become inactive. The action potentials are unable to diffuse along the muscle fibers, which prevents the muscle from contracting in response to the activity initiated by the motor neuron.

Absorption, distribution, and elimination 
Hydrolysed by plasma cholinesterase within a few minutes after being administered intravenously. (A small fraction of the population have an enzyme that has a significantly lower activity level and a longer duration of action.) Given intravenously.

Use in clinical settings 
In order to facilitate tracheal intubation and for short-term surgical procedures, act as  temporary paralysis is administered. Anticholinesterases do not have the ability to reverse the action.

Adverse effects 
There is a possibility of cardiac arrhythmia coupled with hyperkalemia. Hypotension is the condition. There is a bradycardia. Inflammation of the muscles (caused by spasms that occurred during the initial depolarization). Intraocular pressure that is elevated. In extremely rare cases, malignant hyperthermia can occur when used with halothane is used.