​Pharmacology - Venlafaxine

​Pharmacology - Venlafaxine 
Venlafaxine is an antidepressant 

Method of Operation
It does this by inhibiting the reuptake of noradrenaline into neurons that are noradrenergic and 5-HT into neurons that are serotonergic, which boosts the effect of the transmitter substance. The antidepressant effect usually does not become apparent until a few weeks have passed. It does not have any significant impact on the muscarinic, adrenergic, or histamine receptors.
Ingestion of the medication. The active metabolite, desmethylvenlafaxine, has a half-life of five hours. Half life is eleven hours. The cytochrome P450 system does the metabolization in the liver. After 12–24 hours, duloxetine has a half-life.

Clinical Application Depression (said to be effective in circumstances where SSRIs have been unsuccessful). Panic disorder. Disorders of anxiety that are generalized.

Adverse Effects
Symptoms include nausea, headache, difficulty sleeping, and sexual dysfunction. Not administered in conjunction with MAOIs (causes serotonin syndrome). There is a higher likelihood of suicide among younger patients. Depressive symptoms, convulsions, and abnormal heart rhythms are all symptoms of an overdose.