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Symptoms and Signs – Differential Diagnosis of Partial Seizures
• Migraine
• Presyncope
• Psychogenic phenomena, anxiety disorder
• Transient ischemic attack (TIA)
• Migraine
• Presyncope
• Psychogenic phenomena, anxiety disorder
• Transient ischemic attack (TIA)
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Symptoms and Signs – Differential Diagnosis of Pediatric Seizures
FIRST MONTH OF LIFE
First Day
• Hypoxia
• Drugs
• Trauma
• Infection
• Hyperglycemia
• Hypoglycemia
• Pyridoxine deficiency
Day 2–3
• Infection
• Drug withdrawal
• Hypoglycemia
• Hypocalcemia
• Developmental malformation
• Intracranial hemorrhage
• Inborn error of metabolism
• Hyponatremia or hypernatremia
Day >4
• Infection
• Hypocalcemia
• Hyperphosphatemia
• Hyponatremia
• Developmental malformation
• Drug withdrawal
• Inborn error of metabolism
1–6 MONTHS
• As above
6 MONTHS–3 YEARS
• Febrile seizures
• Birth injury
• Infection
• Toxin
• Trauma
• Metabolic disorder
• Cerebral degenerative disease
>3 YEARS
• Idiopathic
• Infection
• Trauma
• Cerebral degenerative disease
FIRST MONTH OF LIFE
First Day
• Hypoxia
• Drugs
• Trauma
• Infection
• Hyperglycemia
• Hypoglycemia
• Pyridoxine deficiency
Day 2–3
• Infection
• Drug withdrawal
• Hypoglycemia
• Hypocalcemia
• Developmental malformation
• Intracranial hemorrhage
• Inborn error of metabolism
• Hyponatremia or hypernatremia
Day >4
• Infection
• Hypocalcemia
• Hyperphosphatemia
• Hyponatremia
• Developmental malformation
• Drug withdrawal
• Inborn error of metabolism
1–6 MONTHS
• As above
6 MONTHS–3 YEARS
• Febrile seizures
• Birth injury
• Infection
• Toxin
• Trauma
• Metabolic disorder
• Cerebral degenerative disease
>3 YEARS
• Idiopathic
• Infection
• Trauma
• Cerebral degenerative disease
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Symptoms and Signs – Differential Diagnosis of Septicemia
• Acute pancreatitis
• Cardiogenic shock
• Collagen-vascular diseases
• Exposure-induced hypothermia
• Fulminant hepatic failure
• Pulmonary embolism
• Systemic vasculitis
• Toxic ingestion
• Acute pancreatitis
• Cardiogenic shock
• Collagen-vascular diseases
• Exposure-induced hypothermia
• Fulminant hepatic failure
• Pulmonary embolism
• Systemic vasculitis
• Toxic ingestion
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Symptoms and Signs – Differential Diagnosis of Serotonin Syndrome
• Alcohol and opioid withdrawal
• Infection
• Neuroleptic malignant syndrome
• Substance abuse (e.g., cocaine, amphetamines)
• Thyroid storm
• Alcohol and opioid withdrawal
• Infection
• Neuroleptic malignant syndrome
• Substance abuse (e.g., cocaine, amphetamines)
• Thyroid storm
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Symptoms and Signs – Differential Diagnosis of Salmonellosis
OTHER CAUSES OF PROLONGED FEVER
• Malaria
• TB
• Brucellosis
• Amebic liver abscess
OTHER CAUSES OF GASTROENTERITIS
• Bacterial: Shigella, Yersinia, Campylobacter
• Viral: Norwalk virus, rotavirus
• Parasitic: Entamoeba histolytica, Giardia lamblia
• Toxic: enterotoxigenic Escherichia coli, Clostridium difficile
OTHER CAUSES OF PROLONGED FEVER
• Malaria
• TB
• Brucellosis
• Amebic liver abscess
OTHER CAUSES OF GASTROENTERITIS
• Bacterial: Shigella, Yersinia, Campylobacter
• Viral: Norwalk virus, rotavirus
• Parasitic: Entamoeba histolytica, Giardia lamblia
• Toxic: enterotoxigenic Escherichia coli, Clostridium difficile
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Symptoms and Signs – Differential Diagnosis of Sarcoidosis
• Alveolar cell carcinoma
• Collagen disorders
• Enlarged pulmonary arteries
• Fibrosing alveolitis
• Hodgkin’s disease
• Hypersensitivity pneumonitis
• Idiopathic hemosiderosis
• Infectious mononucleosis
• Lymphangitic carcinomatosis
• Lymphoma
• Metastases
• Parasitic infection
• Pneumoconioses
• Pulmonary eosinophilia
• TB
• Alveolar cell carcinoma
• Collagen disorders
• Enlarged pulmonary arteries
• Fibrosing alveolitis
• Hodgkin’s disease
• Hypersensitivity pneumonitis
• Idiopathic hemosiderosis
• Infectious mononucleosis
• Lymphangitic carcinomatosis
• Lymphoma
• Metastases
• Parasitic infection
• Pneumoconioses
• Pulmonary eosinophilia
• TB
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Symptoms and Signs – Differential Diagnosis of Scabies
• Atopic dermatitis
• Contact dermatitis
• Dermatitis herpetiformis
• Flea bites
• Nummular eczema
• Other insect infestation
• Pediculosis
• Seborrheic dermatitis
• Syphilis
• Atopic dermatitis
• Contact dermatitis
• Dermatitis herpetiformis
• Flea bites
• Nummular eczema
• Other insect infestation
• Pediculosis
• Seborrheic dermatitis
• Syphilis
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Symptoms and Signs – Differential Diagnosis of Scarlet Fever
• Drug rashes
• Kawasaki’s disease
• Toxic shock syndrome
• Viral exanthems
• Drug rashes
• Kawasaki’s disease
• Toxic shock syndrome
• Viral exanthems
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Symptoms and Signs – Differential Diagnosis of Schistosomiasis
• Amebiasis
• Bacillary dysentery
• Bacterial infections of the urinary tract
• Bowel polyp
• Genitourinary tract cancer
• Prostatic disease
• Amebiasis
• Bacillary dysentery
• Bacterial infections of the urinary tract
• Bowel polyp
• Genitourinary tract cancer
• Prostatic disease
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Symptoms and Signs – Differential Diagnosis of Schizophrenia
• Any medical condition, medicine, or substance of abuse that can affect brain homeostasis and cause psychosis: distinguished from schizophrenia by its relatively brief course and the alteration in mental status that could suggest an underlying delirium
• Autism in the adult: has an early age at onset and lacks significant hallucinations or delusions
• Delusional disorder: has nonbizarre delusions and lacks the thought disturbance, hallucinations, and negative symptoms of schizophrenia
• Mood disorders with psychosis: indistinguishable from schizophrenia cross-sectionally but have a longitudinal course that includes full recovery
• Other neurologic conditions (e.g., Huntington’s) that have psychosis as the initial presentation
• Other psychiatric disorders: source of greatest confusion
• Any medical condition, medicine, or substance of abuse that can affect brain homeostasis and cause psychosis: distinguished from schizophrenia by its relatively brief course and the alteration in mental status that could suggest an underlying delirium
• Autism in the adult: has an early age at onset and lacks significant hallucinations or delusions
• Delusional disorder: has nonbizarre delusions and lacks the thought disturbance, hallucinations, and negative symptoms of schizophrenia
• Mood disorders with psychosis: indistinguishable from schizophrenia cross-sectionally but have a longitudinal course that includes full recovery
• Other neurologic conditions (e.g., Huntington’s) that have psychosis as the initial presentation
• Other psychiatric disorders: source of greatest confusion