Pharmacology - Tamoxifen
Pharmacology - Tamoxifen The Action of Tamoxifen It does this by competing with natural oestrogen for the oestrogen receptor, which makes it impossible for cells to activate and multiply.Orally administered. Clinical Application Clinical Use Breast ca
Pharmacology - Crisantaspase
Pharmacology - Crisantaspase The action of Crisantaspase It is active in tumors (such as acute lymphoblastic leukemia) that have lost the ability to synthesise asparagine and so require an external supply. It is also capable of breaking down asparagine.
Pharmacology - Vincristine
Pharmacology - Vincristine The action of vincristine Attaches to tubulin and stops cells dividing in mitosis before they form spindles.Injected intravenously. Medical Application The malignancies of the blood, lymph nodes, breast, and lungs. Potential
Pharmacology - Paclitaxel
Pharmacology - Paclitaxel Paclitaxel Connects to tubulin and maintains microtubule polymerization, or "freezing," to inhibit the development of spindles during mitosis and cell division. Given by i.v. infusion. Medical Application Cancers of ovary and
Pharmacology - Imatinib
Pharmacology - Imatinib Inhibiting protein kinases is a significant function of imatinib in cancers such as chronic myeloid leukemia. Administered orally and absorbed fully. Medical Application Various types of leukemia, including chronic myeloid, acute
Pharmacology - Doxorubicin
Pharmacology - Doxorubicin Function of Doxorubicin Through its effect on topoisomerase II, it inhibits DNA and RNA production.Administration methods include intravenous infusion (to prevent tissue harm from extravasation) and bladder instillation for blad
Pharmacology - Irinotecan
Pharmacology - Irinotecan In order to hinder cell proliferation, irinotecan binds to topoisomerase I and inhibits it.Given by i.v. infusion Application in Clinical Practice Combined with other agents, colon and rectum metastases. Potential Side Effects
Pharmacology -Dactinomycin
Pharmacology -Dactinomycin Dactinomycin blocks the enzymes RNA polymerase and topoisomerase II by intercalating into DNA. Injected intravenously. Medical Application Paediatric Cancers Potential Side Effects Dyspepsia, vomiting, nausea, and hair loss.
Pharmacology - Cisplatin
Pharmacology - Cisplatin Creates a compound that reacts with DNA, leading to denaturation and cross-linking between individual strands. Given by i.v. infusion. Offered to patients who are not in the hospital. Carboplatin is the chosen treatment for ovar
Pharmacology - Cyclophosphamide
Pharmacology - Cyclophosphamide By establishing covalent bonds with guanine residues on each strand of DNA, cyclophosphamide crosses-links DNA, which disrupts cell division and triggers death. Administration via mouth or intravenous injection leads to it
