Pharmacology - Methotrexate
Pharmacology - Methotrexate Methotrexate Action Interferes with purine synthesis and the production of thymidylate and consequently with DNA synthesis. Mode of Action Competitively inhibits dihydrofolate reductase (DHFR). Clinical Use Given orally, i.v.
Pharmacology - Flurouracil
Pharmacology - Flurouracil Action of Fluorouracil Interferes with the production of dTMP and thus with DNA synthesis. Mode of Action Gives rise to a counterfeit nucleotide and Inhibits thymidylate synthetase. Given i.v. Considering i.v. Clinical Use
Pharmacology - Mercaptopurine
Pharmacology - Mercaptopurine Action of Mercaptopurine Purine analogue that inhibits purine synthesis and gives birth to a false nucleotide. delivered verbally. Keep in mind that the immunosuppressive medication azathioprine is metabolized to mercaptopu
Pharmacology - Cytarabine
Pharmacology - Cytarabine Action of Cytarabine Pyrimidine analogue that is metabolized in the cell to the trisphosphate which inhibits DNA polymerase.given intrathecally, subcutaneously, or IV.Thorough haematological observation is required. Application
Pharmacology - Bleomycin
Pharmacology - Bleomycin leads to the fragmentation of DNA.Considering IV or IM Application in Clinical Practice malignancy of the squamous cell and metastatic germ cell Type II non-Hodgkin lymphoma Side Effects Dose-related pulmonary brosis; skin toxic
Pharmacology - Mebendazole
Pharmacology - Mebendazole The Action of Mebendazole Impairs glucose absorption and other microtubule functions by blocking their production. Orally administered; fatty meals enhance inadequate absorption. Use in Clinical Settings As a result of hookwo
Pharmacology - Levamisole
Action of Levamisole Stimulates nicotinic receptors at the neuromuscular junction, resulting in the worm's tonic paralysis. The eggs are not excreted in the feces, but the paralyzed worms are. To be taken orally; the plasma half-life is four hours. Use
Pharmacology - Piperazine
Pharmacology - Piperazine How Piperazine Works In worms, it turns off the signal that tells the muscles to contract. The paralytic worms are excreted alive in the faeces. Given orally. Use in Clinical Settings Roundworm infection, the common kind. Pre
Pharmacology - Praziquantel
Pharmacology - Praziquantel Praziquantel Action It produces an increase in the calcium permeability of the cell membranes, facilitating calcium inux, resulting in prolonged contraction of muscle with eventual paralysis and death Mode of Action Given
Pharmacology - Ivermectin
Pharmacology - Ivermectin Ivermectin Action Acts at the worm’s neuromuscular junction, inducing paralysis either by increasing GABA-mediated inhibition or by activating an invertebrate-specific glutamate-gated chloride channel. Given orally. Clinical C
