Pharmacology - Pyrimethamine
Pharmacology - Pyrimethamine Action of Pyrimethamine: A schizonticide for slow-acting blood. Action Process The thymidylate synthesis of the malaria parasite is hindered by pyrimethamine because it inhibits the enzyme dihydrofolate reductase (DHFR). An
Pharmacology - Artemether + Lumefantrine
Pharmacology - Artemether + Lumefantrine Artemether and lumefantrine: How They Work Combined blood schizonticides. Action Process The enzyme sarcoplasmic-endoplasmic reticulum calcium ATPase is inhibited by artemether in falciparum. In the parasite foo
Pharmacology - Metronidazole
Pharmacology - Metronnidazole Metronidazole kills Entamoeba histolytica in its motile forms. Effect Mechanism As a result of the drug's metabolism, the trophozoite produces free radicals, which cause DNA damage. It has a half-life of 7 hours when taken
Pharmacology - Diloxanide
Pharmacology - Diloxanide Diloxanide combats Entamoeba histolytica in its non-motile forms. Administered orally, intravenously, or intrarectally; half-life is seven hours. Application in Clinical Practice Following metronidazole treatment, for amoebic d
Pharmacology - Sodium Stibogluconate
Pharmacology - Sodium Stibogluconate The Function of Sodium Stibogluconate Kills protozoa in macrophages, maybe by releasing harmful oxygen radicals. Daily injections into the veins or subcutaneously (painful) for 10-20 days. Clinical Application As a
Pharmacology - Amphotericin
Pharmacology - Amphotericin Activities of Amphotericin It accomplishes this by attaching to the ergosterol that is present in the membrane of fungal cells (which is absent in mammalian cells) and by increasing the permeability of the membrane. Absent fr
Pharmacology - fluconazole
Pharmacology - fluconazole Action Fungistatic by blocking the synthesis of ergosterol - a key component of fungal cell membranes (absent in mammalian cells). Method of Operation Retains The p450-dependent enzyme 14 alpha demethylase is crucial for the
Pharmacology – Terbinafine
Pharmacology – Terbinafine Terbinafine's fungicidal action stems from its inhibition of ergosterol synthesis, a critical component of fungal cell membranes that is absent in mammalian cells. Method of Operation inhibits the enzyme that converts squale
Pharmacology - Caspofungin
Pharmacology - Caspofungin Action Fungicidal via weakening the fungus cell wall. Method of Operation prevents the synthesis of 1,3-beta-D-glucan, which is absent from mammalian cells yet is an essential part of the fungal cell wall. Given i.v. Half-life
Pharmacology - Griseofulvin
Pharmacology - Griseofulvin Fungal cell mitosis is interfered with, resulting in fungistatic action. Method of Operation Interacts with polymerized microtubules limiting spindle formation. When taken orally, it is absorbed by skin cells that are growing
