Pharmacology - Flucytosine
Pharmacology - Flucytosine is changed into the antimetabolite 5-fluorouracil in fungal cells (but not in human cells), which prevents DNA synthesis by blocking thymidylate synthetase.administered orally, but also by intravenous infusion. Plasma half-life
Pharmacology - Inteferon Alpha
Pharmacology - Inteferon Alpha Activity of the Interferon-alpha A virus and virus-infected cells are both eliminated. Method of Operation It does this by stimulating the production of host enzymes, which then degrade viral mRNA (which in turn inhibits
Pharmacology - Chloroquine
Pharmacology - Chloroquine Interaction of Chloroquine A medication that is schizonticidal that destroys malarial parasites that are found in red blood cells. Method of Operation It does this by inhibiting haem polymerase, which is ordinarily responsib
Pharmacology - Quinine
Pharmacology - Quinine How Quinine Works An effective medication against malaria parasites in RBCs, known as a schizonticidal medicine. Mode of Action Theoretically, it protects the parasite from haem by blocking the enzyme that ordinarily breaks it
Pharmacology - Mefloquine
Pharmacology - Mefloquine How Mefloquine Works An effective medication against malaria parasites in RBCs, known as a schizonticidal medicine. Action Process Theoretically, it protects the parasite from haem by blocking the enzyme that ordinarily break
Pharmacology - Primaquine
Action of Primaquine Eliminates liver hypnozoites. Destroys gametocytes. The half-life of this orally administered drug is three to six hours, and it is promptly metabolized. Medical Application In order to eradicate the exo-erythrocytic stage of P. v
Pharmacology - Proguanil
Pharmacology - Proguanil An action of the slow blood schizonticide Action Process Prevents the malaria parasite from producing thymidylate by blocking its enzyme, dihydrofolate reductase (DHFR). Orally administered, the half-life is sixteen hours. Me
Pharmacology - Co-trimoxazole
Pharmacology - Co-trimoxazole Trimethoprim and sulfamethoxazole both prevent bacteria from making DNA by blocking their folate metabolism. Action Technique The enzyme dihydropteroate synthetase is competitively inhibited by sulfamethoxazole. Trimethopr
Pharmacology - Isoniazid
Pharmacology - Isoniazid For dormant mycobacteria, isoniazid acts as a bacteriostat; for actively growing mycobacteria, it kills them all. Mode of Action The production of mycolic acids, which are essential building blocks of mycobacterial cell walls,
Pharmacology - Rifampicin
Pharmacology - Rifampicin Rifampicin kills mycobacteria and a wide variety of other bacteria, including many Gram-negative and most Gram-positive ones. Action Process Inhibits DNA-dependent RNA polymerase, which reduces bacterial RNA synthesis but has
